Information

WELCLOX is brand name of Amoxycillin 250mg + Cloxacillin 250mg. It is an antibiotic useful for the treatment of a number of bacterial infections

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Therapeutic Class

Extended Spectrum Antibiotic and Penicillin Antibiotic

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Dose and Direction of Use

Can be taken with or without food,more preferably after food.

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Mode of Action

Amoxicillin is a semisynthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often referred to as penicillin-binding proteins, PBPs) in the biosynthetic pathway of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to weakening of the cell wall, which is usually followed by cell lysis and death.Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes.

Cloxacillin exerts bactericidal activity via inhibition of bacterial cell wall synthesis by binding one or more of the penicillin binding proteins (PBPs). Exerts bacterial autolytic effect by inhibition of certain PBPs related to the activation of a bacterial autolytic process.

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Uses

• Upper and Lower Respiratory Tract Infections
• Urinary tract infection
• Skin and Skin Structure Infections
• Infected ulcers and burns
• Gonorrhea & Infection of Genital Organs
• Otitis media
• Community acquired pneumonia
• Cystitis,Pyelonephritis
• Bone and joint infections, in particular osteomyelitis.

 

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Contraindications

Don't use this medicine if you have:

• Hypersensitivity to the active substances, to any of the penicillins or to any of the excipients.

• History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam).

• History of jaundice/hepatic impairment due to amoxicillin/clavulanic acid

 

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Precautions and Warning

•  Maintain adequate hydration with high doses 
• Consult with your doctor if you are pregnant or breast feeding woman before taking this medicine to understand the risk and benefit ratio.
• Talk to your doctor about past medical history like kidney problem or liver problem before taking this medicine
• Don't double the dose for the missed one.
• Complete the prescribed dose and duration of medicine.

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